MDMA patents

        
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Owner/AssigneePatent/Pub. No.TitlePriority DateStatusGeneral subject matter
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1Institute Of Science And Technology AustriaWO2021074448A1Stimulation of neuronal plasticity2019-10-18PublishedInducing synchronized gamma oscillations by applying a visual stimulus comprising a flashing light, together in some embodiments with an agent including psychedelics and MDMA
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2University of MarylandWO2021030571A1Methods of Treating Psychological and Brain Disorders2019-08-12PublishedMethods of treating a psychological disorder by administering a 5-HT agonist in combination with a 5-HT2A antagonist, the 5-HT agonists including MDMA
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3Concept Matrix SolutionsUS20210015833A1Oral soft gel capsule containing psychedelic compound2019-07-18Pending in USSoftgels containing “psilocybin, psilocin, baeocystin, mescaline, LSD, ketamine, salvinorin A, ibotenic acid, muscimol, DMT, MDMA, MDEA, MDA, & combinations"
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4Concept Matrix SolutionsUS20210015738A1Oral dissolvable film containing psychedelic compound2019-07-17Pending in USFilms containing “psilocybin, psilocin, baeocystin, mescaline, LSD, ketamine, salvinorin A, ibotenic acid, muscimol, DMT, MDMA, MDEA, MDA, & combinations"
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5Karl Dresdner, Michael Cary, Chase HudsonUS20200345585A1Process for making aqueous therapeutic particle having stable exterior water clustering with nanosized thickness2019-04-30Pending in USProcesses for making aqueous therapeutic nanoparticles, including with cannabinoids, psilocybin and related tryptamines, LSD, MDMA and MDA, ayahuasca, and ketamine
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6The Regents Of The University Of CaliforniaWO2020185581A2Compositions and methods for modulating lipid and steroid metabolism2019-03-08PublishedPromoting colonization of spore-forming bacteria in a patient’ s gut, by administering a serotonin receptor agonist, including mescaline, certain subsituted phenethylamines, and MDMA
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7Apollo NeuroscienceUS20200215297A1Systems and methods of mitigating negative effects of therapies with transcutaneous vibration2019-01-04Pending in USTranscutaneous vibratory simulation during MDMA-assisted psychotherapy
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8Contera PharmaWO2020127954A1Treatment of movement disorders2018-12-20PublishedPharmaceutical compositions for treating movement disorders comprising a 5-HT1A receptor agonist and an indirect dopamine agonist, including MDMA
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9Palo Alto Investors LPUS20200179349A1Methods of Treating Food Allergy Conditions2018-12-06Pending in USTreating a food allergy, by administration of an empathogen or entactogen, including MDMA
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10Douglas MetcalfWO2020061573A1Systems and methods to administer pharmaceuticals2018-09-23PublishedContainers, devices, and methods to administer single doses of drugs by vaporization, including MDMA
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11AlpvisionWO2020049182A1Cognitive computing methods and systems based on biological neural networks2018-09-08PublishedCognitive computing systems based on biological neural networks (BNNs), which may comprise additive chemicals that affect the response of the BNN, including MDMA
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12RejoyUS20200060997A1TARR Receptor Agonists for Sexual Dysfunction2018-08-27Pending in USTopical compositions for female sexual dysfunction, which contract a smooth muscle of the nipple areola complex or increase its sensitivity, comprising trace amine associated receptor agonists, including MDMA
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13Applied Biology, Inc.WO2020023084A1Taar Receptor Agonists For The Treatment Of Alopecia2018-07-26PublishedMethods for treating hair shedding by applying a composition of a pilomotor effective amount of a Taar receptor agonist topically, including MDMA
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14Leon RosenbergWO2020014302A1Therapeutic combinations for treatment of CNS disorders2018-07-11PublishedCombination drugs for treating CNS disorders comprising two or more compounds, one of which may be MDMA
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15Helium 3 Resources PtyWO2020006606A1A pharmaceutical composition and method of use of same2018-07-05PublishedCombination drugs for treating erectile dysfunction and premature ejaculation comprising penile-erection-inducing agents and orgasm-delaying agents, the orgasm-delaying agents including MDMA
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16Robert PetcavichWO2019246532A1Method of inducing dendritic and synaptic genesis in neurodegenerative chronic diseases2018-06-21PublishedTreating neurodegenerative disease by administration of a psychedelic, including MDMA
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17Akili InteractiveWO2019161050A1Cognitive platform including computerized elements coupled with a therapy for mood disorder2018-02-18PublishedComputer systems for mood and cognitive assessment during psychedelic-assisted psychotherapy, including with MDMA
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18EleusisWO2019079742A1Methods and systems for enhancing safety of psychedelic drug therapies2017-10-19PublishedScreening a candidate for treatment with psychedelic and empathogenic agents, including MDMA, based on language characteristics from a language sample
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19Rhodes PharmaceuticalsWO2019074829A1Pharmaceutical resinate compositions and methods of making and using thereof2017-10-09PublishedAnti-tampering and anti-abuse pharmaceutical compositions comprising an ion exchange resin, a binder, and a matrix material, and methods of making same, to be used with drugs including MDMA
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20GW ResearchUS20200237683A1Use of cannabidiol in combination with 5-HT2B receptor agonists or amphetamins in the treatment of epilepsy2017-09-29PublishedTreatments for epilepsy using CBD in combination with a 5-HT2B receptor agonist, amphetamine, or an amphetamine derivative, including MDMA
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21Syneurx International Taiwan CorpUS20190151272A1Lithium salts of N-substituted glycine compounds and uses thereof2017-07-10Pending in USMethods of treating neuropsychiatric disorders, comprising administering a lithium salt of an N-substituted glycine combined in some embodiments with a psychostimulant, including MDMA
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22Syneurx International Taiwan CorpUS10226442B2Lithium salts of N-substituted glycine compounds and uses thereof2017-07-10Granted 2019-03-12 (expires 2037-07-10)Methods of treating neuropsychiatric disorders, comprising administering a lithium salt of N-methylglycine combined in some embodiments with a psychostimulant, including MDMA
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23EleusisUS20200147038A1Assessing and treating psychedelic-responsive subjects2017-04-20Pending in USMethods of screening a subject for treatment and predicting the subject's responsiveness to treatment with a psychedelic or empathogenic agent, including MDMA
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24CaaMTechUS20210085671A1Compositions and methods comprising a combination of serotonergic drugs2017-02-09Pending in USCombinations of two serotonergic drugs, including psilocybin derivatives, tryptamines, cannabinoids, SSRIs, LSD, and MDMA, and use to treat psychological disorders
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25CaaMTechWO2018148605A1Compositions and methods comprising a psilocybin derivative2017-02-09PublishedMethods of modulating activity at a neurotransmitter receptor comprising administering a psilocybin derivative and in some embodiments a serotonergic drug including MDMA
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26Insectergy LLCUS10738268B2Cannabis nanoemulsion methods2016-08-21Granted 2020-08-11 (expires 2036-11-01)
Methods to produce cannabis oil nanoemulsions with various compounds including MDMA
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27Mamood ValadiUS20180042292A1Cigarette-like device for administration of substances2016-08-15AbandonedVaporizer and aerosolizer devices for inhalation of substances including MDMA
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28Stanford UniversityUS10641782B2Methods for visualization and quantification of fiber-like structures2016-05-25Granted 2020-05-05 (expires 2037-07-26)Methods for visualizing fiber-like structures in biological specimens, including where the specimen is from a subject animal exposed to MDMA
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29Gruenenthal GmbHUS20170071862A1Protecting oral overdose with abuse deterrent immediate release formulations2015-09-10Pending in USDosage forms comprising a drug embedded in a polymer matrix to prevent overdose after accidental or intentional administration of multiple such dosage forms, the drugs including MDMA
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30University of South FloridaUS10821107Inhibitors of the FKBP51 protein from a high-throughput drug screen and methods of use2015-06-30Granted 2020-11-03 (expires 2035-06-30)Methods of treating a neurodegenerative disease or condition, depression, a stress disorder, or an anxiety disorder, with a drug including MDMA, where the patient has one or more FKBP5 gene variants
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31Mclean HospitalXenon and/or argon treatment as an adjunct to psychotherapy for psychiatric disorders2012-12-11PendingMethods of treating PTSD and psychiatric disorders using xenon and/or argon, in combination with psychotherapy, and in some embodiments in combination with MDMA
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32GlyTechUS10202469B2Sugar chain-attached linker, compound containing sugar chain-attached linker and physiologically active substance or salt thereof, and method for producing same2012-11-30Granted 2019-02-12 (expires 2033-12-11)Glycosylated drug conjugates (i.e., a glycosylated linker bonded to an active substance) having improved water solubility and release profile, the active substances including MDMA
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33 SipNoseUS10549052B2Nasal delivery device2012-02-28Granted 2020-02-04 (expires 2036-06-13)Nasal delivery devices using compressed air for intranasal "direct nose-to-brain" administration of drugs including MDMA
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34Tokyo Metropolitan Institute of Medical ScienceUS20170357750A1Method for evaluating drug sensitivity and disease vulnerability by analyzing cyclic amp responsive element binding protein gene2011-09-30AbandonedMethods for evaluating drug sensitivity using genetic polymorphisms, the drugs including MDMA
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35Gosforth Centre (Holdings) PtyUS20140142140A1Pharmaceutical composition for neurological disorders2011-07-08AbandonedCompositions and methods for treating neurological disorders comprising a sub-therapeutic dose of an anti-epileptic agent and a stimulant, including MDMA
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36Christian Terreaux et al.US20130295179A1Novel omega-3 and omega-6 fatty acid compositions and uses thereof2010-10-12AbandonedCompositions for treating mental disorders and for improving mental health comprising DHA, EPA, and GLA, combined with a psychostimulant, including MDMA
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37Emory UniversityUS20120108510A1Methods of improving behavioral therapies2010-05-20AbandonedPsychedelic-assisted psychotherapy using an oxytocin releasing agent, including MDMA
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38Auspex PharmaceuticalsUS20100172916A1Substituted hydroxyphenylamine compounds2008-11-10AbandonedMethod of treating a hormone-mediated disorder or pigment-mediated disorder comprising administration of compounds which may be in combination with additional therapeutic agents, including MDMA
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39Gosforth Centre (Holdings) PtyUS10028971B2Compositions and methods for treating psychiatric disorders2008-08-08Granted 2018-07-24 (expires 2029-08-06)Methods of treating mild cognitive impairment using an anti-epileptic agent and optionally one or more psychostimulants, the psychostimulants including MDMA
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40Univ. South Florida; US Dep't Veterans AffairsUS20190167653A1Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with a-beta peptide aggregation2008-06-30PendingMethods of treating a stress disorder or condition by using cotinine (a nicotine metabolite) together in some embodiments with MDMA; methods "can be used in combination with...various forms of psychotherapy"
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41Oron ZacharUS20110144209A1Use of vasoconstrictors2008-06-30AbandonedMethods of treating cancer by drug-induced hyperthermia caused by administering a vasoconstrictor, including MDMA
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42Daniel SchwartzUS20090264475A1Methods and compositions for altering dietary behavior2008-01-24AbandonedMethods of altering dietary behavior, by adding one or more positively-reinforcing compounds into healthy foods, the compounds including MDMA
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43Pisgah LabsUS10183001B1Opioid and attention deficit hyperactivity disorder medications possessing abuse deterrent and anti-dose dumping safety features2007-05-22Granted 2019-01-22 (expires 2027-10-13)Drug products with improved safety and anti-abuse properties, comprising a matrix of BNDO and an active compound, including MDMA
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44Pisgah LabsUS9421266B2Safety of pseudoephedrine drug products2007-05-22Granted 2016-08-23 (expires 2027-10-05)Drug products with improved safety and anti-abuse properties, by the inclusion of alditol acetals to reduce bioavailability in the mucosal membranes, the active compounds including MDMA
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45Pisgah LabsUS20080293695A1Salts of physiologically active and psychoactive alkaloids and amines simultaneously exhibiting bioavailability and abuse resistance2007-05-22AbandonedDrug products that can be administered therapeutically but having anti-abuse properties when used non-therapeutically, the active compounds including MDMA
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46Auspex PharmaceuticalsUS20080045588A1Preparation and utility of substituted amphetamines2006-08-02AbandonedDeuterated amphetamines including MDMA and MDA, processes of their preparation, pharmaceutical compositions thereof, and methods of their use for the treatment and/or management of trauma, e.g., PTSD
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47Duke UniversityUS8877802B2Antiparkinsonian action of phenylisopropylamines2005-07-28Granted 2014-11-04 (expires 2033-03-04)Methods of treating Parkinson's disease comprising administering synergistic amounts of L-Dopa in combination with MDMA
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48Randal J. KirkUS20090239783A1Synergistic effects of combined administration of mirtazapine and a stimulant compound2004-11-08AbandonedCompositions of a stimulant and mirtazapine, where the stimulant can include MDMA; methods of their use and manufacture
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49ShireUS20060100136A1Synergistic effects of combined administration of mirtazapine and a stimulant compound2004-11-08AbandonedCompositions of a stimulant and mirtazapine, where the stimulant can include MDMA; methods of their use and manufacture
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50Mayo Foundation, NIH, DHHSUS20080033029A1Treating digestive tract conditions2004-05-06AbandonedMethods for treating a digestive tract condition by administering a serotonin receptor agonist, including MDMA
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51Lohmann Therapie Systeme GmbHUS8980308B2Transdermal pharmaceutical preparation containing active substance combinations, for treating Parkinson's disease2003-08-20Granted 2015-03-17 (expires 2029-07-04)Transdermal pharmaceutical preparations for treating Parkinson's disease containing L-Dopa and other active agents including MDMA
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52Agouron Pharmaceuticals, PfizerUS20040224960A1Pharmaceutical compositions and methods for their use2003-02-21AbandonedMethods of increasing the bioavailability of drugs by coadministration of a CYP450-inhibiting compound, the drugs including MDMA
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53PfizerUS20020013372A1Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors2000-03-14AbandonedMethods of generating pharmacophore models for the CYP2D6 inhibitory potency of SSRIs for in silico drug screening, including by using MDMA in a training set of compounds
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54PfizerUS20030144220A1Use of CYP2D6 inhibitors in combination therapies1999-04-07AbandonedMethods of administering drugs that are metabolized by CYP2D6 in combination with a CYP2D6 inhibitor, to improve the drugs' pharmacokinetic profile, the drugs including MDMA
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55University of MinnesotaUS5028611ATreatment for cocaine use1989-06-29Granted 1991-07-02 (expired 2009-06-29)Method for reducing cravings and the use of psychostimulants and psychoactive compounds comprising orally administering carbamazepine, the compounds including MDMA
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56Yale UniversityUS5059600ATreating habit disorders1989-03-31Granted 1991-10-22 (expired 2009-03-31)Methods of treating drug disorders comprising administering flupenthixol, the drug disorders including addiction to, abuse of, or dependency on MDMA
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57Thomas HosickUS4120976ATreatments for arthritis and cast dermatitis1977-12-13Granted 1978-10-17 (expired 1997-12-13)Methods of relieving the symptoms of arthritis and cast dermatitis comprising administering MDA (note: not MDMA) in dosage amounts of approximately 0.2 to 1.5 mg/kg of body weight.
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58MerckDE279194Verfahren zur Darstellung von Hydrastinin Derivaten1912-12-24Granted 1914-10-15 (expired)Method of coverting MDMA to methylhydrastinine, a methylated analogue of hydrastinine ("Process for the preparation of hydrastinine derivatives")
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59MerckDE274350Verfahren zur Darstellung von Alkyloxyaryl-, Dialkyloxyaryl- und Alkylendioxyarylaminopropanen bzw. deren am Stickstoff monoalkylierten Derivaten1912-12-24Granted 1914-05-16 (expired)Method of synthesizing MDMA ("Process for the preparation of alkyloxyaryl, dialkyloxyaryl and alkylenedioxyarylaminopropanes and their derivatives monoalkylated on the nitrogen")
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