“The real puzzles this brew presents pertain, I think, neither to botany nor to culture but rather to the human mind. As such, the study of ayahuasca belongs first and foremost to the domain of psychology, and more specifically cognitive psychology – the discipline investigating the workings of the human mind.”
Shanon, B. (1997). Cognitive psychology and the study of ayahuasca. Jahrbuch Für Ethnomedizin Und Bewusstseinsforschung/Yearbook for Ethnomedicine and the Study of Consciousness, 6, 77–94.
Psilocybe induced rejuvenation
Let me know if I’m reading this right or wrong.
First Psilocybe’s receptor profile:
You can see it hits 5-HT2 receptors, as well as dopamine receptors
Importantly, utilizing receptor selective antagonists, we have demonstrated that the mechanism underlying the systemic anti-inflammatory effects of (R)-DOI is activation of serotonin 5-HT2A receptors.
The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.
In addition, DOI accelerated the recovery of mitochondrial function after oxidant-induced injury in RPTC. This is the first report to demonstrate 5-HT receptor-mediated mitochondrial biogenesis, and we suggest that 5-HT-agonists may be effective in the treatment of mitochondrial and cell injury.
The personality changes also ran counter to those expected as people age. Normally, as people grow older, they become increasingly less open to new ideas and new experiences. In contrast, in participants who experienced had what researchers call a “full mystical experience,” the scientists saw a shift toward increased openness, as though the volunteers had become decades younger.
It can be concluded that ketanserin may affect the testosterone-secreting cells by an indirect action at the vascular level as well as directly at the level of Leydig cells, at least in adolescent rats, leading to down-regulation of the basal testosterone secretion.
Note: Ketanserin is an antagonist, meaning it blocks the effects of agonists like Psilocin and other tryptamines.
Very interesting here, a role of 5HT2A receptor polymorphisms in human life expectancy:
Telomere Length in a Population of LongLived People of the Northwestern Region of Russia
Combining analysis of telomere lengths, age of respondents, and distribution of genotypes of gene of serotonin receptor 5HTR2A (Fig. 6), we observe practical absence of genotype A1A1 in the senior age group and its association with the shorter telomeres in other age groups. The genotype A2A2, on the contrary, is characterized by its predominant presence in respondents of the senior age group; however, differences in association with telomere lengths between it and the genotype A1A2 in other age groups were not detected. These data correspond to the association of the genotype A2A2 with active longevity, which we have showed earlier (Smirnova et al., 2011).
At the same time, strongly pronounced differences in the 5-HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected.
I’d dare to wager that psilocin and other 5-HT2A agonists may have some sort of rejuvenating effect on the human body.