Category Archives: Varia

Ayahuasca & CogPsy

“The real puzzles this brew presents pertain, I think, neither to botany nor to culture but rather to the human mind. As such, the study of ayahuasca belongs first and foremost to the domain of psychology, and more specifically cognitive psychology – the discipline investigating the workings of the human mind.”

Shanon, B. (1997). Cognitive psychology and the study of ayahuasca. Jahrbuch Für Ethnomedizin Und Bewusstseinsforschung/Yearbook for Ethnomedicine and the Study of Consciousness, 6, 77–94.

Psilocybe induced rejuvenation (Reddit)


Psilocybe induced rejuvenation from DrugNerds

Psilocybe induced rejuvenation

Let me know if I’m reading this right or wrong.

First Psilocybe’s receptor profile:

www.neurosoup.com/psilocin/

You can see it hits 5-HT2 receptors, as well as dopamine receptors

journals.plos.org/plosone/article?id=10.1371/journal.pone.0075426

Importantly, utilizing receptor selective antagonists, we have demonstrated that the mechanism underlying the systemic anti-inflammatory effects of (R)-DOI is activation of serotonin 5-HT2A receptors.

www.ncbi.nlm.nih.gov/pubmed/16601191

The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.

www.ncbi.nlm.nih.gov/pubmed/19875674

In addition, DOI accelerated the recovery of mitochondrial function after oxidant-induced injury in RPTC. This is the first report to demonstrate 5-HT receptor-mediated mitochondrial biogenesis, and we suggest that 5-HT-agonists may be effective in the treatment of mitochondrial and cell injury.

healthland.time.com/2011/10/03/want-to-feel-younger-more-open-magic-mushrooms-trigger-lasting-personality-change/

The personality changes also ran counter to those expected as people age. Normally, as people grow older, they become increasingly less open to new ideas and new experiences. In contrast, in participants who experienced had what researchers call a “full mystical experience,” the scientists saw a shift toward increased openness, as though the volunteers had become decades younger.

www.ncbi.nlm.nih.gov/pubmed/10482255

It can be concluded that ketanserin may affect the testosterone-secreting cells by an indirect action at the vascular level as well as directly at the level of Leydig cells, at least in adolescent rats, leading to down-regulation of the basal testosterone secretion.

Note: Ketanserin is an antagonist, meaning it blocks the effects of agonists like Psilocin and other tryptamines.

Very interesting here, a role of 5HT2A receptor polymorphisms in human life expectancy:

link.springer.com/article/10.1134/S1990519X12050112

Telomere Length in a Population of LongLived People of the Northwestern Region of Russia

Combining analysis of telomere lengths, age of respondents, and distribution of genotypes of gene of serotonin receptor 5HTR2A (Fig. 6), we observe practical absence of genotype A1A1 in the senior age group and its association with the shorter telomeres in other age groups. The genotype A2A2, on the contrary, is characterized by its predominant presence in respondents of the senior age group; however, differences in association with telomere lengths between it and the genotype A1A2 in other age groups were not detected. These data correspond to the association of the genotype A2A2 with active longevity, which we have showed earlier (Smirnova et al., 2011).

link.springer.com/article/10.1134/S2079057012030149

At the same time, strongly pronounced differences in the 5-HT2A gene A1 and A2 alleles in populations of the northwestern region of the Russian Federation and the United States (0.397 (A1) and 0.603 (A2), and 0.615 (A1) and 0.385 (A2), respectively) were detected.

Conclusion:

I’d dare to wager that psilocin and other 5-HT2A agonists may have some sort of rejuvenating effect on the human body.

Gilgamesh and the Magic Plant

Flood Tablet of the Epic of Gilgamesh

Veenker, R. A.. (1981). Gilgamesh and the Magic Plant. The Biblical Archaeologist, 44(4), 199–205.

Plain numerical DOI: 10.2307/3209664
DOI URL
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Source URL: stmuscholars.org/gilgamesh-the-search-for-immortality/

Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects

Aday, J. S., Davis, A. K., Mitzkovitz, C. M., Bloesch, E. K., & Davoli, C. C.. (2021). Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects. ACS Pharmacology & Translational Science, 4(2), 424–435.

Plain numerical DOI: 10.1021/acsptsci.1c00014
DOI URL
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The subjective experience of acute, experimentally-induced Salvia divinorum inebriation

Addy, P. H., Garcia-Romeu, A., Metzger, M., & Wade, J.. (2015). The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. Journal of Psychopharmacology, 29(4), 426–435.

Plain numerical DOI: 10.1177/0269881115570081
DOI URL
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Identification of a novel member of the family Betaflexiviridae from the hallucinogenic plant Salvia divinorum

GOH, C. J., & HAHN, Y.. (2019). Identification of a novel member of the family Betaflexiviridae from the hallucinogenic plant Salvia divinorum. Acta Virologica, 63(04), 373–379.

Plain numerical DOI: 10.4149/av_2019_401
DOI URL
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Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action

Coffeen, U., & Pellicer, F.. (2019). Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action. Journal of Pain Research, Volume 12, 1069–1076.

Plain numerical DOI: 10.2147/JPR.S188619
DOI URL
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Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats

Vázquez-León, P., Arenas-Martínez, U., Córdova-Maqueda, D., Fregoso-Aguilar, T., Juan, E. R.-S., & Miranda-Páez, A.. (2021). Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats. Acta Neurobiologiae Experimentalis, 81(1), 34–42.

Plain numerical DOI: 10.21307/ane-2021-005
DOI URL
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